在1型糖尿病患者抵抗运动期间,量化胰岛素介导和非胰岛素介导的葡萄糖动态变化
Gavin M Young1, Peter G Jacobs1, Nichole S Tyler2
1Artificial Intelligence for Medical Systems (AIMS) Laboratory, Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, United States.
在1型糖尿病 (T1D) 中,抵抗运动 (RE) 不会显著改变血糖水平. 非胰岛素介导的葡萄糖吸收在RE期间增加,这可能解释了与有氧运动相比降低低血糖风险.
科学领域:
- 内分泌学 在内分泌学.
- 代谢过程中的代谢.
- 运动生理学 运动生理学
背景情况:
- 有氧运动可以导致1型糖尿病 (T1D) 患者的危险血糖波动.
- 阻力运动 (RE) 对T1D葡萄糖动态的影响不太清楚.
- 了解RE期间的葡萄糖调节对于管理糖尿病和运动安全至关重要.
研究的目的:
- 研究中度和高强度抵抗运动对1型糖尿病患者葡萄糖代谢的影响.
- 在抵抗运动期间量化内源性葡萄糖生产 (EGP) 和葡萄糖处置 (Rd).
- 在T1D中,在抵抗运动期间区分胰岛素介导和非胰岛素介导的葡萄糖利用.
主要方法:
- 25名患有T1D的参与者接受了三次中度或高强度抵抗运动.
- 用一种葡萄糖追踪器技术来测量葡萄糖动力学.
- 使用数学建模来估计EGP和Rd,并确定胰岛素介导和非胰岛素介导的葡萄糖利用率.
主要成果:
- 平均而言,在抵抗运动期间,血糖水平保持稳定.
- 在RE期间内源性葡萄糖生产 (EGP) 增加,而葡萄糖处置 (Rd) 也增加.
- 非胰岛素介导的葡萄糖利用率在运动期间显著增加,在运动后恢复到基线,而胰岛素介导的利用率保持不变.
结论:
- 抵抗运动不会导致T1D患者血糖的平均变化.
- 在RE期间观察到非胰岛素介导的葡萄糖利用率的增加可能会减轻低血糖风险.
- 研究结果表明,与有氧运动相比,抵抗运动可能是T1D患者在血糖控制方面更安全的选择.
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