休时间的体力活动和胃癌风险:在胃癌联合项目 (StoP) 项目中进行的一项合并研究
Marco Mariani1, Roberta Pastorino1,2, Denise Pires Marafon1
1Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.
PloS one
|July 12, 2023
概括
身体活动 (PA) 没有显示出与胃癌 (GC) 风险的总体联系. 然而,更高的PA可能会在55岁以下的个体和使用基于人口的对照时略微降低GC风险.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 在瘤学瘤学.
背景情况:
- 身体活动 (PA) 与包括癌症在内的多种疾病风险降低有关.
- 休时间的PA与胃癌 (GC) 之间的具体关系需要进一步研究.
研究的目的:
- 为了估计休时间PA和GC发生之间的关联.
- 在胃癌聚合 (StoP) 项目中对病例控制研究的综合分析分析数据进行分析.
主要方法:
- 六项病例控制研究的聚合分析 (2,343个GC病例,8,614个控制).
- 科目的分类为没有/低,中等或高的休时间PA类别.
- 应用多变量逻辑回归和随机效应模型来进行聚合效应估计.
主要成果:
- 与低PA相比,中等/高PA和GC风险之间没有显著的关联.
- 在55岁以下的个体中观察到高PA的潜在的GC风险降低 (OR0.72).
- 在基于人群的对照研究中观察到潜在的GC风险降低 (OR 0.79).
结论:
- 休时间的PA与整体GC风险没有显著的关联.
- 在年轻人 (年龄 ≤55) 中,可能存在PA对GC风险的可能保护作用.
- 研究设计,特别是对照组的选择,可能会影响PA-GC风险关联的发现.
相关概念视频
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Gastric Emptying
957
Gastric emptying occurs when the stomach gradually releases chyme into the duodenum. When the stomach is distended, it triggers the release of gastrin, a hormone that promotes gastric acid secretion to aid in digestion. Additionally, stomach distension contributes to peristaltic waves that propel gastric contents toward the pyloric region. The gastroenteric reflex, on the other hand, primarily stimulates peristalsis in the intestines, facilitating the movement of contents further along the...
957
Assessment of the Gastrointestinal System II: Health Perception Pattern
143
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
143
Gastric Phase of Digestion
1.2K
The gastric phase of digestion begins as soon as food enters the stomach. The incoming food bolus triggers neural and hormonal mechanisms, which last approximately 3 to 4 hours. During this phase, the stomach undergoes significant changes to prepare the food for further digestion and absorption.
When food enters the stomach, it stretches the stomach walls and activates stretch receptors. This triggers local reflexes of the enteric nervous system, mediated through the myenteric plexus. These...
When food enters the stomach, it stretches the stomach walls and activates stretch receptors. This triggers local reflexes of the enteric nervous system, mediated through the myenteric plexus. These...
1.2K
Gastric Motility
847
Gastric motility is the coordinated contraction and relaxation of stomach muscles that convert ingested food into chyme, a semi-liquid substance ready for further digestion in the intestines. The process begins with the vagus nerve inducing the relaxation of the smooth muscles in the fundus and body of the stomach, allowing these regions to expand and accommodate up to approximately 1.5 liters of food and liquid.
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
847
Barrett Esophagus-I: Introduction
133
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
133


