丹麦怀孕妇女在20年期间的甲状腺功能过高症
Nanna Maria Uldall Torp1,2, Zeyan Liew3,4, Allan Carlé2,5
1Department of Clinical Biochemistry, Aalborg University Hospital, 9000 Aalborg, Denmark.
The Journal of clinical endocrinology and metabolism
|July 12, 2023
概括
在丹麦强制增添强化后,怀孕妇女
科学领域:
- 内分泌学和新陈代谢学
- 公共卫生和流行病学
- 生殖医学 生殖医学
背景情况:
- 在怀孕期间甲状腺功能过高会带来临床挑战.
- 监测甲状腺功能障碍的患病率至关重要,特别是在强化计划后.
- 丹麦在2000年实施了强制性强化.
研究的目的:
- 评估丹麦孕妇甲状腺功能障碍和抗甲状腺药物 (ATD) 使用的变化.
- 在20年内评估围绕强制性强化 (IF) 的这些变化.
主要方法:
- 使用了全国范围的基于登记的队列 (1997-2016).
- 包括两个带有生物化学数据的出生队列:丹麦国家出生队列 (1997-2003) 和北丹麦地区怀孕队列 (2011-2015).
- 分析了母亲的ATD使用和怀孕早期的生化甲状腺功能障碍的频率.
主要成果:
- 与基线 (1997-1999) 相比,ATD治疗的调整几率比率在IF后 (2001-2004) 增加了1.51.
- 西丹麦的增长率 (aOR 1.67) 比东丹麦的增长率 (aOR 1.30) 大,随访后恢复到基线.
- 在怀孕早期没有发现与时间相关的显著差异生化甲状腺功能过高.
结论:
- 丹麦的母体ATD使用在IF实施后增加,然后稳定.
- 这些发现与一般人口趋势一致,表明IF对年轻人自身免疫性甲状腺功能障碍的影响.
- 强化似乎影响了自身免疫性甲状腺功能障碍的发生率.
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