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开始HIV治疗后体重增加:病理生理学和影响

Nomathemba C Chandiwana1, Mark J Siedner2, Vincent C Marconi3

  • 1Ezintsha, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.

The Journal of clinical endocrinology and metabolism
|July 12, 2023
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概括

现代艾滋病毒治疗 (ART) 提高了预期寿命,但可能导致艾滋病毒感染者 (PLWH) 体重增加和肥胖,特别是黑人个人和妇女. 本综述探讨了与ART相关的体重增加的原因,影响和干预措施.

关键词:
艾滋病病毒 艾滋病病毒 艾滋病病毒抗逆转录病毒治疗的治疗方法代谢后果 代谢后果肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖体重增加 体重增加

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科学领域:

  • 传染性疾病 传染性疾病
  • 内分泌学 在内分泌学.
  • 代谢障碍 代谢障碍 代谢障碍

背景情况:

  • 现代抗逆转录病毒疗法 (ART) 已经改变了艾滋病毒/艾滋病的管理,导致艾滋病毒感染者 (PLWH) 的预期寿命接近正常.
  • 矛盾的是,体重增加和肥胖症已经成为PLWH在ART上的重大挑战,与历史的历史形成鲜明对比.
  • 瘦身疾病是一种瘦身疾病.
  • 与早期艾滋病毒/艾滋病相关.
  • 这种现象在治疗开始时不成比例地影响黑人,女性和晚期免疫缺陷患者.

研究的目的:

  • 审查接受ART的PLWH体重增加的病理生理学和影响.
  • 探讨这个问题最近得到认可的原因,尽管几十年来有效的治疗.
  • 讨论潜在的原因,代谢后果和干预策略.

主要方法:

  • 关于艾滋病毒,ART,体重增加和肥胖的综合文献综述.
  • 分析拟议的病因理论,包括从消耗中恢复,ART疗程的比较效果和直接药物效应.
  • 检查与ART相关的体重增加的代谢和炎症后果.
  • 审查当前和新兴的干预选择来管理PLWH的肥胖.

主要成果:

  • 在ART的体重增加是一个复杂的问题,有多因素的原因,与历史上的消耗不同.
  • 与ART相关的体重增加与对脂质,葡萄糖代谢和炎症标志物的不良影响有关.
  • 特定的ART疗法和药物可能会对体重增加产生差异性影响.
  • 干预策略有限,突出了需要进一步研究的需要.

结论:

  • 体重增加和肥胖是PLWH中现代ART的重大并发症,最近得到了认可.
  • 了解病理生理学对于管理代谢并发症至关重要.
  • 需要进一步的研究来开发有效的干预措施,包括新的抗肥胖药物,用于在ART时体重增加的PLWH.