在2型慢性鼻炎鼻息肉与喘并发症时,多西环素可能在临床上更有效
Gülden Paçacı Çetin1, Bahar Arslan1, İnsu Yılmaz1
1Department of Chest Disease, Division of Immunology and Allergy, Erciyes University School of Medicine, Kayseri, Türkiye.
概括
多环素显著改善了带有鼻息肉的慢性鼻炎 (CRSwNP) 的症状,特别是在喘患者中. 这种附加疗法为CRSwNP患者提供症状控制.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 药理学 药理学是指药理学的学科.
背景情况:
- 带有鼻息肉的慢性鼻鼻炎 (CRSwNP) 呈现出显著的症状负担.
- 多西环林是一种潜在的附加疗法,用于管理CRSwNP.
研究的目的:
- 评估口服多西环素在改善CRSwNP患者视觉模拟尺度 (VAS) 和中鼻结局测试 (SNOT-22) 评分方面的短期疗效.
主要方法:
- 一项回顾性队列研究分析了28名CRSwNP患者,他们接受了100毫克多克西环素治疗21天.
- 在治疗前和治疗后评估了VAS和SNOT-22分数.
- 根据喘,阿托皮,IgE和色素水平,分组检查了疗效.
主要成果:
- 在鼻后滴水,鼻水,堵塞和打喷的VAS分数以及总SNOT-22分数 (p<0.001) 中观察到显著改善.
- 嗅觉丧失的VAS没有显著改善 (p=0.18).
- 喘小组在所有VAS和SNOT-22得分中显示出显著的改善. 非喘小组仅在SNOT-22得分上有显著改善.
结论:
- 多西环林证明了作为CRSwNP.症状控制的附加治疗的有效性.
- 在CRSwNP患者患有并发性喘时,这种益处尤其显著.
相关概念视频
COPD: Management Using Bronchodilators and Corticosteroids
249
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
249
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
308
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
308
Drugs Used in Lower Respiratory Disorders: Overview
499
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
499
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
351
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
351
Drugs Used in Upper Respiratory Disorders: Overview
292
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
292
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
348
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
348


