脱氧尼瓦伦醇:新兴的毒性机制和控制策略,当前和未来的前景
Journal of agricultural and food chemistry
|July 12, 2023
概括
脱氧尼瓦伦醇 (DON) 是一种常见的食品污染物,会引起毒性影响. 研究探讨了它对氧化应激,信号通路和肠-大脑轴的影响,突出显示了未来的生物降解策略.
科学领域:
- 食品安全和毒理学
- 分子生物学和细胞信号传递
- 微生物学和肠道健康
背景情况:
- 脱氧尼瓦伦醇 (DON) 是食品和料中普遍存在的真菌毒素,对人类和动物健康构成风险.
- 毒性涉及复杂的机制,包括氧化应激,MAPK信号和缺氧诱导因子-1α激活.
- 新兴研究表明,DON的毒理特征涉及非编码RNA,Wnt/β-catenin,FOXO和TLR4/NF-κB通路.
研究的目的:
- 审查和综合当前关于Deoxynivalenol (DON) 毒性的基础分子机制的知识.
- 突出肠道微生物群和脑肠轴在DON诱导的生长抑制中的作用.
- 确定DON检测,生物控制和生物降解的当前和未来研究重点.
主要方法:
- 文献综述和对DON毒性机制现有研究的综合.
- 对信号通路的分析,包括MAPK,Wnt/β-catenin,FOXO和TLR4/NF-κB.
- 检查肠道微生物群和大脑-肠轴对DON效应的影响.
主要成果:
- 唐毒性由氧化应激,MAPK激活和HIF-1α介导,影响活性氧物种和亡.
- 非编码RNA和特定的信号通路参与了DON的有害影响.
- 肠道微生物群和脑肠轴在DON诱导的生长抑制中至关重要.
结论:
- 了解DON多方面的毒性机制对于风险评估和缓解至关重要.
- 与其他真菌毒素的协同作用需要全面的控制策略.
- 未来的研究应该集中在DON检测,生物控制和酶生物降解上,以便在市场上应用.
关键词:
在Wnt/β-catenin中使用.生物降解 生物降解大脑-肠轴 - 大脑-肠轴脱氧尼瓦伦诺 (deoxynivalenolenol) 是一种除氧剂.在 lncRNA 中,这是一个小RNARNA.更多相关视频
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