把敌人变成宽容的宿主:通过细胞内细菌操纵巨细胞两极分化
Trung Hm Pham1, Denise M Monack2
1Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Current opinion in immunology
|July 12, 2023
概括
像沙门氏菌这样的细胞内细菌将巨细胞,通常与病原体作斗争的免疫细胞重新编程为允许的复制. 这种对巨细胞两极分化的操纵是细菌生存和发病的一个关键策略.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 细胞生物学 细胞生物学
背景情况:
- 巨细胞是具有抗微生物功能的重要免疫哨兵.
- 然而,它们可以作为细胞内的病原体,如沙门氏菌.
- 巨细胞极化状态影响它们的抗菌活性和病原体宽容性.
研究的目的:
- 审查沙门氏菌重编程巨细胞的机制.
- 突出细菌操纵巨细胞两极分化作为一种致病策略.
- 讨论塑造巨细胞状态和功能的因素.
主要方法:
- 审查关于细菌效应机制的现有文献.
- 对沙门氏菌操纵宿主细胞极化策略的分析.
- 讨论对巨细胞的微环境和本体遗传影响.
主要成果:
- 沙门氏菌和其他细胞内细菌将毒性因子注入巨细胞质中.
- 这些效应器重编程巨细胞,扭曲它们的两极分化,以创造一个宽容的利基.
- 细菌对巨细胞进行重编程是一种保存的病原生成策略.
结论:
- 细菌对巨细胞两极分化的操纵是病变发生的一个关键方面.
- 了解巨细胞的功能多样性是开发新疗法的关键.
- 需要进一步的研究来探索细菌效应因子,环境和巨细胞本体发生的相互作用.
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