禁食和热量限制对性别和时间的特定影响
Sebastian J Hofer1, Frank Madeo1
1Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria; Field of Excellence BioHealth, University of Graz, Graz, Austria; BioTechMed Graz, Graz, Austria.
Cell metabolism
|July 12, 2023
概括
优化食物摄入量和禁食时间表可以改善健康和寿命. 热量限制与禁食相结合显示出希望,特别是在老年雌性小鼠中,这表明性别和年龄会影响饮食干预的有效性.
科学领域:
- 营养科学 营养科学
- 老年学是一门学科.
- 时间生物学 时间生物学
背景情况:
- 饮食干预措施,如卡路里限制 (CR) 和间歇性禁食,正在探索健康益处.
- 个人因素,如性别,年龄和昼夜节律,可能会显著影响干预的有效性.
- 新兴的研究调查了这些因素和饮食策略之间的相互作用.
研究的目的:
- 总结当前关于性别,年龄和昼夜时间如何影响饮食干预结果的知识.
- 要突出关于老年雌性小鼠中CR和禁食的组合的具体发现.
主要方法:
- 关于饮食干预的新兴知识的文献评论.
- 对特定研究结果的分析 (Duregon等人). 在老年雌性小鼠身上.
主要成果:
- 性,年龄和昼夜时间被确定为饮食干预成功的关键决定因素.
- 热量限制和禁食的组合在老年雌性小鼠中表现出有利的结果.
结论:
- 饮食干预措施,包括CR和禁食,可以通过考虑性别,年龄和昼夜因素来优化.
- 在老年雌性小鼠中发现的结果表明,结合CR和禁食对老年人群的潜在益处.
相关概念视频
Metabolic States of the Body: Fasting and Starvation
1.5K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
1.5K
Metabolic States of the Body: The Postabsorptive State
378
The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
378
Hormonal Regulation of the Menstrual Cycle
456
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
456


