Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Predicting Molecular Geometry02:27

Predicting Molecular Geometry

VSEPR Theory for Determination of Electron Pair Geometries

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Asbestos-Related Respiratory Diseases in Spain: Insights From the Spanish Registry.

American journal of industrial medicine·2026
Same author

Longitudinal associations of psychological distress with subsequent cognitive decline and dementia: a multi-cohort study.

medRxiv : the preprint server for health sciences·2025
Same author

Exploring the impact of 'hostile environment' policies on psychological distress of ethnic groups in the UK: a differences-in-differences analysis.

Social psychiatry and psychiatric epidemiology·2024
Same author

Temporal patterns in the recorded annual incidence of common mental disorders over two decades in the United Kingdom: a primary care cohort study.

Psychological medicine·2023
Same author

The APPLE Tree programme: Active Prevention in People at risk of dementia through Lifestyle, bEhaviour change and Technology to build REsiliEnce-randomised controlled trial.

Trials·2022
Same author

Community interventions for improving adult mental health: mapping local policy and practice in England.

BMC public health·2021

相关实验视频

Updated: Jul 20, 2026

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

40.8K

预测粒子沉积使用一个简化的8路径在化物人类肺的原型.

R Barrio-Perotti1, N Martín-Fernández2, C Vigil-Díaz3

  • 1Departamento de Energía, Universidad de Oviedo, and GRUBIPU-ISPA, Gijón, Spain.

Journal of breath research
|July 12, 2023
PubMed
概括

一个新的简化肺模型使用计算流体动力学准确预测粒子沉积. 这种多路径方法为环境和药物输送研究的实验方法提供了具有成本效益的替代方案.

关键词:
8路肺模型的肺部模型差价合约 (CFD) 的计算与计算边界条件的边界条件是颗粒沉积过程中的颗粒沉积

更多相关视频

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models
07:56

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models

Published on: November 11, 2020

4.3K
In vitro Cannabis Exposures of Lung Epithelial Cells at the Air-Liquid Interface
07:05

In vitro Cannabis Exposures of Lung Epithelial Cells at the Air-Liquid Interface

Published on: June 20, 2025

224

相关实验视频

Last Updated: Jul 20, 2026

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

40.8K
Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models
07:56

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models

Published on: November 11, 2020

4.3K
In vitro Cannabis Exposures of Lung Epithelial Cells at the Air-Liquid Interface
07:05

In vitro Cannabis Exposures of Lung Epithelial Cells at the Air-Liquid Interface

Published on: June 20, 2025

224

科学领域:

  • 计算流体动力学 计算流体动力学
  • 呼吸系统建模呼吸系统建模
  • 粒子运输现象 粒子运输现象

背景情况:

  • 准确的颗粒沉积预测对于环境健康和药物输送至关重要.
  • 实验方法是昂贵的,并涉及风险.
  • 现有的计算模型由于资源需求而面临局限性.

研究的目的:

  • 开发和验证一个简化的,计算效率高的粒子沉积肺部模型.
  • 改进现有的简化模型,以提高预测准确度.
  • 为了使患者特定的分析和药物输送系统设计的帮助.

主要方法:

  • 使用3D计算流体动力学 (CFD) 方法.
  • 开发了肺气道的8路近似.
  • 实施了截断流枝的新型边界条件.
  • 模拟稳定吸入在18L/分钟,不同的颗粒大小和密度.

主要成果:

  • 简化模型提供了相当准确的粒子沉积预测.
  • 以完全的气道模型计算成本的一小部分获得准确的结果.
  • 证明了对粒子大小和密度效应的明确评估.
  • 与单路径模型相比,显示了更好的准确性和区域沉积率预测.

结论:

  • 经过验证的多路径缩小气道模型为粒子沉积分析提供了高效和准确的工具.
  • 这种方法适用于一般研究和特定患者的应用.
  • 该模型有助于设计改进的药物输送系统和环境暴露评估.