在早期的移植后期循环的"中性粒细胞外细胞陷"与移植功能障碍和排斥相关
Mahendra Kumar1, Deepesh B Kenwar2, Aravind Sekar3
1Department of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Transplant immunology
|July 12, 2023
概括
中性粒细胞外细胞陷 (NETs) 在移植后增加,可能表明缺血-再输液损伤 (IRI). 需要进一步的研究来证实它们在移植结果中的作用.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 免疫学 免疫学 免疫学
- 移植生物学 移植生物学
背景情况:
- 中性粒细胞外细胞陷 (NETs) 与各种疾病有关,包括感染,自身免疫和缺血-再输液损伤 (IRI).
- 在早期移植损伤和移植结果中,NETs的作用尚不清楚.
- 这项研究调查了移植接受者 (KTRs) 在移植后早期期间的循环NET.
研究的目的:
- 在移植后对移植接受者 (KTRs) 进行循环NET水平的评估.
- 为了将NET水平与早期移植结果和缺血-再输液损伤 (IRI) 相关联.
- 评估NETs,氧化应激标志物和移植功能之间的关系.
主要方法:
- 对30名移植接受者 (KTRs) 的前性研究,分为非功能障碍和功能障碍组.
- 血清NET水平 (髓氧化酶-DNA复合物) 在移植前,8小时和移植后18小时测量.
- 测量了IRI的标志物马隆迪化 (MDA) 水平,并与NET和移植结果相关联.
主要成果:
- 在两组中,循环NET在移植后8小时内显著增加,然后减少18小时.
- 在任何时间点,在非功能障碍和功能障碍组之间没有观察到NET水平的显著差异.
- 虽然MDA显示出与NETs相似的趋势,表明与IRI的潜在联系,但只有肌素显示出与NETs和MDA都有显著的反相关性.
结论:
- 在KTR中,在移植后的早期,循环NET升高,无论早期的移植结果如何.
- 网络和MDA的类似动态表明,网络可能是IRI响应的一部分.
- 需要进行更长的随访时间的大型研究,以确定关于NET和移植结果的最终结论.
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