暴露于ZnO纳米颗粒诱导血液-牛奶屏障功能障碍,通过破坏紧密的连接和细胞损伤损伤细胞
Jingjing Wang1, Mingzhen Jiang1, Guangchao Wan1
1College of Life Science and Engineering, Foshan University, Foshan, Guangdong 528231, China.
Toxicology letters
|July 12, 2023
概括
氧化纳米颗粒 (ZnO-NPs) 伤害乳腺,增加牛奶污染. 这些纳米颗粒通过破坏细胞结节并引起炎症和氧化应激来破坏血液-牛奶屏障.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 纳米技术纳米技术
背景情况:
- 氧化纳米颗粒 (ZnO-NPs) 被广泛使用,引发了环境和健康方面的担忧.
- ZnO-NP可以在器官中积累,可能会破坏生物障碍.
- 尚不完全了解ZnO-NPs对血液-牛奶屏障的影响.
研究的目的:
- 调查ZnO-NPs影响血乳屏障功能的机制.
- 为了确定ZnO-NPs对乳腺组织和牛奶成分的影响.
- 阐明涉及ZnO-NP诱导屏障功能障碍的细胞和分子通路.
主要方法:
- 哺乳小鼠被暴露在ZnO-NPs中.
- 进行了乳腺组织病理学分析.
- 使用FITC-albumin评估了血液-牛奶屏障的透性.
- 分析了紧结蛋白的表达.
- 研究了NF-κB和MAPK的信号通路.
- 测量了氧化应激标志物 (铁的积累,脂质氧化).
主要成果:
- 在乳腺中积累了ZnO-NP,导致了他的病理损伤.
- ZnO-NPs增加了血液-牛奶屏障的透性,由FITC-白蛋白扩散证明.
- 紧结蛋白表达被改变,削弱了屏障.
- ZnO-NPs激活了NF-κB和MAPK通路,诱导了炎症.
- 增加的铁积累和脂质氧化表明氧化损伤和铁亡.
结论:
- ZnO-NPs诱导了他的病理损伤,并积聚在乳腺中,污染了牛奶.
- 通过影响紧密的接口和增加透性,ZnO-NP破坏了血液-牛奶屏障的完整性.
- 炎症,氧化应激和铁致死有助于ZNO-NP诱导的乳腺功能障碍.
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