补充EPA和DHAomega-3脂肪酸可以改善周围免疫细胞线粒体功能障碍和肥胖患者的炎症
Angélica I Borja-Magno1, Janette Furuzawa-Carballeda2, Martha Guevara-Cruz1
1Department of Nutritional Physiology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Ciudad de México, Mexico.
The Journal of nutritional biochemistry
|July 12, 2023
概括
补充omega-3脂肪酸 (w-3FA) 改善了线粒体功能,并减少了肥胖患者的炎症性免疫细胞. 这项研究研究了w-3FA对肥胖患者外周血液单核细胞 (PBMC) 的影响.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢过程中的代谢.
- 营养科学 营养科学
背景情况:
- 欧米茄-3脂肪酸 (w-3FA) 具有抗炎性质,并增强线粒体功能.
- 关于w-3FA对周围血液单核细胞 (PBMC) 线粒体生物能学在肥胖症中的影响的数据有限.
研究的目的:
- 评估线粒体生物能学和肥胖中的PBMC子集组成.
- 评估1个月w-3FA补充剂对肥胖个体这些参数的影响.
主要方法:
- 病例控制研究比较瘦身和肥胖个体.
- 在肥胖者接受 w-3 FA 补充剂 (5.25 g/天 EPA/DHA) 的干预前后研究.
- 对PBMC线粒体生物能标记物和免疫细胞子集的分析.
主要成果:
- 与瘦个体相比,肥胖个体的PBMC呼吸率较高,但生物能量健康指数 (BHI) 较低.
- 在肥胖人群中观察到免疫细胞 (Th1,Th2,Th17,Tregs,Bregs,M1单细胞,pDCregs) 的比例增加.
- w-3FA补充改善了线粒体功能 (增加了储备容量和BHI,减少了非线粒体呼吸) 并减少了循环免疫细胞子集.
结论:
- 肥胖与PBMC线粒体功能障碍和免疫细胞简介的改变有关.
- 一个月的EPA和DHA补充剂有效地改善了线粒体功能,并在肥胖患者中调节了免疫细胞群.
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