含有凝和拉巴胺素的混合聚合物热凝用于转移性胰腺癌治疗
Seo Yeon Kim1, Min Jeong Jo1, Moon Sup Yoon1
1College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea.
概括
这项研究开发了一种新型的热敏凝,用于胰腺癌的腹腔内化疗. 优化的凝含有吉姆西塔和拉帕米显示出协同作用的抗瘤效应,在小鼠中没有观察到毒性.
科学领域:
- 生物医学工程 生物医学工程
- 在瘤学瘤学.
- 药物输送系统 药物输送系统
背景情况:
- 胰腺管腺癌 (PDAC) 的死亡率很高,预后不佳.
- 腹腔内化疗提供治疗效益,但需要安全有效的输送策略.
- 结合治疗与凝胺 (GEM) 和拉帕 (RAPA) 显示了增强抗癌活性的潜力.
研究的目的:
- 开发和描述一种热敏凝,用于通过腹腔内注射同时输送GEM和RAPA,用于PDAC治疗.
- 评估开发的药物载凝的体外细胞毒性和体内抗瘤疗效和安全性.
主要方法:
- 制备一个热敏的多酸乳合甘油) -b-多酸乙烯甘油) -b-多酸乳合甘油) (PLGA-PEG-PLGA) 凝装载有GEM和RAPA.
- 在体外细胞毒性测定中使用Panc-1-luc2瘤球体来评估协同作用的药物效应.
- 在小鼠体内药物释放研究和抗瘤疗效和毒性的评估.
主要成果:
- 优化的GEM/RAPA载荷凝 (g(GR)) 在体外表现出协同作用的抗癌作用,与对照组相比,抑制率高出2.75倍.
- 在体内研究表明,从凝中迅速释放药物,g(GR) 显示出最高的抗瘤疗效,在小鼠中没有可观察到的毒性.
- 凝系统在48小时内降解,表明良好的体内行为.
结论:
- 开发的热敏PLGA-PEG-PLGA凝是一种安全有效的平台,用于PDAC的GEM和RAPA的腹腔内联合输送.
- 这种配方有望在局部抗癌疗法中临床转化.
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