基于前段OCT的角度封闭的深度学习分类.
Jing Shan1, Zhixi Li2, Ping Ma3
1Department of Ophthalmology, University of California, San Francisco, San Francisco, California.
Ophthalmology. Glaucoma
|July 12, 2023
概括
卷积神经网络 (CNN) 模型显示,使用OCT扫描识别初级角关闭疾病 (PACD) 是有前途的. 虽然对于一般的PACD检测是有效的,但区分像初级近视角疑似 (PACS) 和初级近视角玻璃眼 (PACG) 这样的阶段需要进一步细化.
科学领域:
- 眼科医生 眼科 眼科
- 人工智能的人工智能
- 医疗成像医学成像
背景情况:
- 主要视角闭合疾病 (PACD) 是视力丧失的重要原因之一.
- 准确和有效的诊断对于及时干预至关重要.
- 前段光学连贯性断层扫描 (AS-OCT) 提供了眼睛结构的详细成像.
研究的目的:
- 评估卷积神经网络 (CNN) 模型的性能和通用性,以识别PACD.
- 评估CNNs使用AS-OCT图像区分PACD阶段的能力.
- 确定CNN在高通量查和诊断中的有效性.
主要方法:
- 一项涉及中国和新加坡眼科中心患者的横截面研究.
- 使用AS-OCT图像对三个CNN分类器进行培训和验证.
- 第1分类:控制与PACS与PAC+PACG;第2分类:控制与PACD;第3分类:PACS与PAC+PACG.
- 在独立验证套件和跨国测试套件上进行评估.
主要成果:
- 分类器2表现出强大的概括性,在验证时达到0.96的曲线下的面积 (AUC),在测试组中达到0.95.
- 分类器1在区域上表现良好 (AUC 0.96),但在测试组中概括性降低 (AUC 0.84).
- 第三种分类表现最差,AUC为0.83 (验证) 和0.64 (测试).
结论:
- 通过使用AS-OCT,CNN模型可以有效地将PACD与健康对照区分开来,具有良好的跨队列概括性.
- 在区分初级近视角疑似病 (PACS) 和初级近视角玻璃眼 (PACG) 之间,CNN的性能适度.
- 可能需要进一步的研究来提高PACD分期中的CNN准确性.
相关概念视频
01:28Angle Closure Glaucoma: Treatment
574
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
574
01:27Open Angle Glaucoma: Treatment
481
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
481
01:25Glaucoma: Overview
623
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
623