使用药物分泌度估计药物代谢
Agnes Cua1, Kevin Krock1, Richard Thomas1
1Precision Diagnostics LLC, San Diego CA, USA.
Annals of clinical and laboratory science
|July 12, 2023
概括
定量性尿液药物测试可以估计药物代谢动力学. 尿液中原药与代谢物的比率表明从第一阶代谢转向零阶代谢,有助于估计药物剂量.
科学领域:
- 药理学 药理学是指药理学的学科.
- 分析化学 分析化学
- 毒理学 毒理学 毒理学
背景情况:
- 了解药物代谢对于确定安全有效的剂量至关重要.
- 像氧可,可,芬太尼等阿片类药物,以及像布普伦诺芬和美沙等阿片类药物表现出复杂的药物动力学特征.
- 准确的药理动力学估计有助于临床管理和过量预防.
研究的目的:
- 提出一种新的方法来估计常见阿片类药物和相关药物的零顺序和第一顺序药理动力学,使用尿液中药物度.
- 为了研究尿液中代谢物与原始药物比率的实用性,用于药理动力学估计.
- 根据尿液的药理动力学数据,对选定药物的和剂量进行估计.
主要方法:
- 使用液体染色学-并联质谱法 (LC-MS/MS) 进行尿样的定量分析.
- 测量母药物 (氧化,,布普伦诺啡,甲,芬太尼) 和它们的代谢物.
- 计算尿液中的代谢比率 (代谢物与原始药物)
- 药物动力学原理的应用和关于生物可用性和尿液分泌的假设.
主要成果:
- 观察到母药量与代谢比率之间的相关性,较高的母药水平与降低的代谢比率相关.
- 这种反向关系表明,随着药物度的增加,新陈代谢从第一阶段转向零阶段 (和).
- 对研究药物成功开发了和剂量的估计,并纳入了生物可用性和尿液分泌的假设.
结论:
- 通过LC-MS/MS分析的定量尿液药物度,提供了一种可行的非侵入性方法来估计药物的药理动力学.
- 尿液代谢比率是代谢途径和的有价值指标,特别是在零阶动力学方面.
- 这种方法为估计药物和点和为临床实践提供信息提供了一个有希望的工具,特别是在管理阿片类药物治疗和监测药物使用方面.
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