相关实验视频

Updated: Jul 23, 2025

Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model

Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model

Published on: November 26, 2010

最近在准骨髓系衍生抑制细胞方面的进展及其在放射治疗中的应用

Zi-Zhan Li¹, Jing-Yu He², Qiuji Wu³

¹The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China; Department of Oral & Maxillofacial Head Neck Oncology, School & Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China.

International review of cell and molecular biology

|July 12, 2023

概括

通过药物递送系统 (DDS) 准髓质衍生抑制细胞 (MDSC) 显示出增强癌症放射治疗的前景. 在逆转免疫抑制和克服治疗耐药性方面,DDS提供了提高效率和降低毒性.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
纳米技术纳米技术

背景情况:

骨髓原抑制细胞 (MDSCs) 是癌症免疫抑制的关键调节者,促进瘤生长和治疗耐药性.
目前针对MDSC的策略在治疗效率方面存在局限性.
放射治疗是癌症治疗的基石,但MDSCs可以赋予耐药性.

研究的目的:

在癌症治疗中,系统地审查旨在向髓质衍生抑制细胞 (MDSC) 的药物递送系统 (DDS).
分析针对MDSC的DDS的作用机制.
评估针对MDSC的DDS在辐射敏感化中的作用.

主要方法:

对针对癌症中MDSC的DDS研究的综合文献搜索.
基于它们对MDSC的作用机制,对DDS的分类.
审查MDSC生物学及其在癌症进展和转移中的作用.
对DDS介导的放射敏感化效应的分析.

主要成果:

最近DDS的进展表明,针对MDSC的开发,招募,差异化和消除是有效的.
DDSs在逆转MDSC介导的免疫抑制方面显示出潜力.
用DDS针对MDSC可以克服放射治疗耐药性并改善治疗结果.

结论:

DDSs代表了针对MDSC的有希望的策略,以增强癌症免疫疗法和放射治疗.
针对MDSC的DDS的进一步开发对于提高癌症治疗效率和克服耐药性至关重要.
DDSs,MDSC向和放射治疗的组合具有显著的治疗潜力.

关键词:

癌症癌症癌症癌症药物输送系统是药物输送系统.来自骨髓细胞的抑制细胞.放射性敏感化是一种放射性敏感化.放射疗法是一种放射治疗.

更多相关视频

Preparation of Myeloid Derived Suppressor Cells MDSC from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting AutoMACS

Preparation of Myeloid Derived Suppressor Cells MDSC from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting AutoMACS

Published on: June 18, 2012

Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting

Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting

Published on: June 18, 2018

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.