结合放射治疗和NK细胞疗法:现在是时候了
Jérémy Baude1, Emeric Limagne2, Riad Ladjohounlou3
1Radiation Oncology Department, Preclinical Radiation Therapy and Radiobiology Unit, Centre Georges-François Leclerc, Unicancer, Dijon, France.
International review of cell and molecular biology
|July 12, 2023
概括
自然杀手 (NK) 细胞对于抗瘤免疫是至关重要的,但在固体瘤中效果较差. 将放射治疗与NK细胞疗法相结合可能会增强抗瘤反应并改善固体瘤治疗.
科学领域:
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
- 辐射疗法 辐射疗法
背景情况:
- 自然杀手 (NK) 细胞是通过免疫监测和瘤微环境 (TME) 的细胞因子调节对抗瘤反应至关重要的先天免疫细胞.
- 基于T细胞的免疫疗法的进步刺激了对基于NK细胞的疗法的兴趣,在白血病中显示出希望,但在固体瘤中面临局限性.
研究的目的:
- 审查放射治疗对NK细胞介导的抗瘤反应的影响.
- 探索将放射治疗与NK细胞向治疗相结合的策略,以改善固体瘤治疗.
主要方法:
- 关于电离辐射对NK细胞和TME的影响的文献综述.
- 在放射治疗的背景下分析有关NK细胞功能的现有数据.
主要成果:
- 放射治疗对NK细胞和TME的影响是复杂的,取决于输送方法和瘤模型,可能导致促炎或免疫抑制的环境.
- 电离辐射对NK细胞活动和抗瘤功能的确切影响仍然不完全理解.
结论:
- 放射治疗可以调节免疫TME,为增强基于NK细胞的免疫疗法提供了机会.
- 将放射治疗与NK细胞向治疗相结合,有可能恢复NK细胞的抗瘤活性,并改善固体瘤的结果.
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