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在不同程度的胰岛素敏感度的非肥胖男性中,骨肌肉整体蛋白表达

Róża Aleksandrowicz¹, Magdalena Stefanowicz², Marek Strączkowski¹

¹Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Białystok 15-540, Poland.

Endocrine journal

|July 12, 2023

概括

骨肌的整合蛋白表达与健康男性的胰岛素敏感性 (IS) 降低有关. 这表明细胞外矩阵因素可能会影响胰岛素的作用,即使是在早期胰岛素抵抗的发展.

科学领域:

肌肉生理学肌肉生理学
代谢健康代谢健康
细胞外矩阵生物学细胞外矩阵生物学

背景情况:

骨肌肉细胞外矩阵 (ECM) 改造与胰岛素抵抗 (IR) 相对应.
集成蛋白调解细胞-ECM通信,影响细胞内信号传递.
了解整合素在骨肌肉胰岛素敏感性 (IS) 中的作用至关重要.

研究的目的:

调查骨肌肉整合素表达和健康,非肥胖的年轻男性的IS之间的关系.
为了确定与不同程度的胰岛素敏感性相关的特定整合素.

主要方法:

在36名健康男性中评估IS的高胰岛素-高血糖.
大侧肌肉活检用于整体mRNA表达分析.
统计分析以将整合素表达与IS和代谢参数相关联.

主要成果:

下部IS体表现出更高的腰围,身体脂肪和脂质配置文件.
在下IS tertile中观察到ITGA5,ITGA6,ITGA7和SPARC的表达增加.
ITGA2,ITGA3,ITGA5,ITGA6,ITGA7和SPARC的mRNA水平与IS.相反地相关.

结论:

骨肌肉整合素表达与健康的非肥胖男性的胰岛素敏感性降低有关.
肌肉中的ECM相关因素可能会在IR发育早期调节胰岛素作用.
综合素代表了理解和管理代谢健康的潜在目标.

关键词:

胰岛素耐药性胰岛素耐药性是一种对胰岛素敏感的胰岛素敏感整合物是一种整合物.骨架肌肉是一个骨肌肉.

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