身体症状和大脑形态:一项对12286名青春期前青少年进行的人口神经成像研究
Fernando Estévez-López1,2,3, Hannah H Kim4, Mónica López-Vicente5
1Department of Social and Behavioral Sciences, Harvard T. H. Chan School of Public Health, Boston, MA, USA. fer@estevez-lopez.com.
Translational psychiatry
|July 12, 2023
概括
在青春期前,更多的身体症状与前额叶皮层表面积的减少有关. 这项神经成像研究表明,微妙的脑形态差异可能与身体症状体验有关.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 放射学 放射学是一门学科.
背景情况:
- 身体症状或身体症状缺乏明确的医学原因,并且在神经生物学上解释不一致.
- 现有的研究依赖于小型的临床病例控制研究.
研究的目的:
- 调查身体症状与青春期前青少年大脑形态之间的关联.
- 为了区分特定于身体症状的脑形态学关联与伴随性焦虑/抑郁症.
主要方法:
- 对两个大型,基于人口的队列 (R世代和ABCD研究) 的横截面研究.
- 使用儿童行为检查清单 (CBCL) 评估身体症状的体质投诉尺度.
- 使用3特斯拉结构性MRI分析全球大脑指标和基于表面的测量 (皮质表面积和厚度).
- 跨队列的研究结果的元分析.
主要成果:
- 在几个大脑区域,包括轨道前皮层和岛屿中,在身体症状和表面积之间发现了负面关联.
- 像左侧轨道前皮层和右侧三角皮层这样的特定区域显示出与身体症状独特的关联.
- 对于皮质厚度没有观察到任何显著的关联.
结论:
- 青春期前的身体症状与前额叶皮层表面积的减少略有相关.
- 这些发现突出了微妙的神经发育差异,可能与身体症状有关.
- 需要进一步的纵向研究来确定身体症状和大脑变化之间的因果关系.
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