一个全球数据库,用于建模瘤-免疫细胞通信.
Yunjin Xie1, Weiwei Zhou1, Jingyi Shi1
1College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
Scientific data
|July 12, 2023
概括
一个新的数据库,TICCom,模型瘤免疫细胞 (TIC) 通信. 它整合了验证和预测的相互作用,为癌症研究和理解瘤免疫力提供了全面的资源.
科学领域:
- 癌症免疫学 癌症免疫学
- 计算生物学是一种计算生物学.
- 生物信息学是一种生物信息学.
背景情况:
- 瘤细胞和免疫细胞通信,影响瘤免疫力.
- 关于瘤-免疫细胞 (TIC) 通信的现有知识在众多研究中分散.
- 在各种癌症中对ICT通信进行系统的表征是具有挑战性的.
研究的目的:
- 开发一个全面的数据库,TICCom,用于模拟ICT通信.
- 巩固实验验证和计算预测的ICT互动.
- 为研究癌症中的ICT通信提供一个集中资源.
主要方法:
- 从3000多个文献来源收集了739个经过实验验证或手动策划的ICT互动.
- 使用6个计算算法推断了4,537,709个预测的相互作用.
- 在25种癌症类型中重新分析了32个scRNA-seq和大量RNA-seq数据集.
- 集成的联体受体相互作用和功能信息.
主要成果:
- TICCom模拟了瘤细胞和14种类型的免疫细胞之间的通信.
- 该数据库包含14,190个人类和3,650个小鼠集成的连接体-受体相互作用.
- 包括这些相互作用的补充功能信息.
结论:
- TICCom作为一个有价值的,全面的资源,用于调查瘤-免疫细胞通信.
- 促进了跨不同癌症类型的TIC相互作用的系统表征.
- 帮助研究人员了解塑造瘤免疫力的复杂相互作用.
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