评估用于机械通风的电脑神经刺激模式:一个试点研究
Arnhold Lohse1, Philip von Platen2, Carl-Friedrich Benner2
1Medical Information Technology, Faculty of Electrical Engineering and Information Technology, RWTH Aachen University, 52072, Aachen, Germany. lohse@hia.rwth-aachen.de.
Scientific reports
|July 12, 2023
概括
电动神经刺激可以防止机械通风期间的隔膜缩. 最佳参数,特别是双相脉冲,最大限度地提高潮体积,以获得更好的患者结果.
科学领域:
- 生物医学工程 生物医学工程
- 呼吸系统生理学 呼吸系统生理学
- 关键护理医学 关键护理医学
背景情况:
- 机械通风通常会导致隔膜缩,延长患者的断奶时间.
- 电脑神经刺激 (EPNS) 提供了一种潜在的解决方案,以维持镇静患者的隔膜条件.
- 优化EPNS参数对于实现充足的通风和防止肌肉衰竭至关重要.
研究的目的:
- 系统地评估一个原型EPNS系统的刺激模式调整.
- 为了确定最大化潮体积的最佳刺激参数.
- 制定EPNS临床应用的指导方针.
主要方法:
- 一个原型EPNS系统在两个猪模型中进行了评估.
- 潮体积被用作刺激效率的主要指标.
- 进行了脉冲频率和脉冲宽度的系统调整.
主要成果:
- 与交替脉冲相比,双相脉冲产生了更一致的潮体积.
- 潮的体积随着脉冲频率和宽度的增加而增加,在80-120 Hz和0.15 ms.
- 在生成的潮体积和刺激脉冲频率之间观察到显著的正相关性.
结论:
- 特定的EPNS参数组合,特别是在定义的频率和宽度范围内的双相脉冲,最大限度地提高潮体积.
- 该研究为设定EPNS参数提供了指导方针,有助于未来的临床实施.
- 在机械通风患者中,EPNS显示了预防隔膜缩和促进断奶的潜力.
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