针对DMARDs对疫苗免疫原性的影响
Yannick van Sleen1, Kornelis S M van der Geest2, Anke L W Huckriede3
1Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, the Netherlands. y.van.sleen@umcg.nl.
Nature reviews. Rheumatology
|July 12, 2023
概括
疾病修饰性抗风湿药物 (DMARDs) 可以削弱对流感和SARS-CoV-2等疫苗的免疫反应. 对于接受DMARD治疗的患者来说,需要新的疫苗接种策略,以确保对严重感染的保护.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
- 疫苗学 疫苗学 疫苗学
背景情况:
- 疫苗对于预防免疫受损个体的严重感染至关重要,例如那些使用疾病修饰性抗风湿药物 (DMARD) 的疫苗.
- 治疗DMARD可以抑制免疫系统,可能会降低疫苗的疗效.
- 在这种情况下,流感和SARS-CoV-2疫苗已被广泛研究.
研究的目的:
- 审查各种DMARDs对流感和SARS-CoV-2疫苗免疫性的影响.
- 阐明DMARDs干扰疫苗反应的机制.
- 突出需要在接受DMARD治疗的患者中改进疫苗接种策略.
主要方法:
- 文献审查侧重于研究DMARDs和疫苗反应的研究.
- 对接受DMARD治疗的患者流感和SARS-CoV-2疫苗免疫性数据的分析.
- 检查DMARDs影响的免疫路径.
主要成果:
- B细胞枯竭疗法,美诺酸莫菲蒂尔,环胺,阿扎西奥普林和阿塔切显著降低了疫苗的免疫性.
- 葡萄糖皮质类药物,甲铁酸盐,TNF抑制剂和JAK抑制剂对疫苗反应的影响不太清楚,可能取决于剂量.
- DMARDs 损害了关键免疫细胞 (APC,T细胞,B细胞) 和有效疫苗接种所必需的过程.
结论:
- 某些DMARDs显著损害疫苗反应,需要修改的疫苗接种方法.
- 了解DMARD诱导的免疫失调是优化疫苗疗效的关键.
- 开发创新的疫苗接种策略对于保护DMARD治疗患者免受严重传染病的保护至关重要.
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