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相关概念视频

Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

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工程前列腺癌在体外:需要什么?

Adriana Buskin1, Emma Scott1, Ryan Nelson1

  • 1Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Paul O'Gorman Building, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

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前列腺癌 (PCa) 的异质性挑战了治疗. 先进的3D有机体模型对个性化疗法有希望,但需要进行工程改进,以更好地模仿瘤微环境和转移.

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科学领域:

  • 在瘤学瘤学.
  • 生物技术是生物技术.
  • 组织工程是组织工程.

背景情况:

  • 前列腺癌 (PCa) 呈现出显著的分子,细胞和临床异质性,使治疗复杂化,导致治疗失败.
  • 目前的临床前模型难以完全回顾这种多样性和耐药表型,阻碍了有效的个性化PCa疗法的开发.
  • 三维 (3D) 器官模型已经成为强大的工具,反映了异质性,并使基因组/环境操纵能够用于疾病建模和药物查中的应用.

研究的目的:

  • 审查当前的体外3D前列腺癌模型,重点是有机体.
  • 讨论开发更具生理相关性的PCa有机体模型的工程方法.
  • 增强有机体模型对前列腺癌精密医学的翻译相关性.

主要方法:

  • 对前列腺癌3D模型,特别是有机体模型的当前文献的综述.
  • 分析用于癌症模型开发的组织工程技术进步.
  • 讨论在有机体模型中改善瘤微环境和表观基因组复制的策略.

主要成果:

  • 有机技术在模拟PCa异质性和药物反应方面具有显著的优势.
  • 现有的有机体模型在完全复制瘤微环境,转移和表观基因组方面存在局限性.
  • 工程方法具有创造先进的3DPCa模型的潜力,具有改进的体内功能.

结论:

  • 进一步设计3D有机体模型对于克服当前的局限性至关重要.
  • 改进的PCa有机体模型将改善临床前研究,加速精准医学的发展.
  • 优化器官模型是实现其充分潜力的关键,以改变前列腺癌治疗.