在新生儿重症监护病房治疗肺炎的短期抗生素治疗
Zachery S Lewald1,2,3,4, Pavel Prusakov5, Jacqueline K Magers5
1The Ohio State University, Columbus, OH, USA.
概括
在NICU治疗血培养阴性肺炎的5天抗生素疗程显示了高坚持性,并且似乎是安全的. 大多数婴儿完成了治疗,很少需要重新开始抗生素治疗.
科学领域:
- 新生儿医学 新生儿医学
- 儿童传染病 儿童传染病
- 临床药房 临床药房
背景情况:
- 肺炎是新生儿重症监护室 (NICU) 中常见的感染.
- 优化抗生素持续时间对于管理新生儿肺炎和预防耐药性至关重要.
- 血培养阴性肺炎带来了诊断和治疗的挑战.
研究的目的:
- 为了评估对新生儿血培养负性肺炎的5天抗生素治疗方案的坚持.
- 评估与这种治疗方案相关的安全结果,包括抗生素重新开始和死亡率.
主要方法:
- 从2020年8月到2021年12月,在7个NICU对肺炎的婴儿进行前性监测.
- 定义的安全结果包括在14天内重新开始服用抗生素和死亡率 (总体和与败血症相关).
主要成果:
- 在119名患有肺炎的婴儿中,88%的婴儿接受了为期5天的最终抗生素治疗.
- 在接受5天治疗的患者中,只有3%需要为肺炎重新开始服用抗生素.
- 总体死亡率为5%,其中7例死亡中有5例归因于败血症.
结论:
- 观察到对培养负性肺炎的5天抗生素治疗的高度坚持.
- 5天的抗生素疗程在这个新生儿群体中显示出安全的特征.
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