患有大脑鼻静脉血栓的儿童的特征和结果
Juan Sebastian Proaño1, Paul A Martinez2,3, Prithvi Sendi2,3
1Marshall University Joan C Edwards School of Medicine, 1600 Medical Center Drive, Huntington, WV, 25705, USA. proanocoello@marshall.edu.
Neurocritical care
|July 12, 2023
概括
大脑鼻静脉血栓形成症 (CSVT) 在儿童中很少见,每10万人中发生26.3例. 儿科CSVT中风并发症增加死亡率,需要机械通风.
科学领域:
- 儿科神经学 儿科神经学
- 血管神经学 血管神经学
- 流行病学 流行病学
背景情况:
- 大脑鼻静脉血栓形成 (CSVT) 是儿童的一种罕见但严重的疾病.
- 对于儿科CSVT存在有限的大规模流行病学数据.
研究的目的:
- 评估在美国接受CSVT治疗的住院儿童的流行病学.
- 评估诊断为CSVT的儿科患者的住院结果.
主要方法:
- 使用2016年和2019年的儿童住院患者数据库进行了回顾性横截面分析.
- 使用CSVT和相关疾病的特定诊断代码.
- 雇员样本权重用于国家流行率和结果估计.
主要成果:
- 每10万例儿科出院中,CSVT发生在26.3例,年龄分布呈U字形.
- 19.3%的儿童患有中风 (出血或缺血),与较高的死亡率 (OR 2.3) 和通风需求 (OR 2.7) 相联系.
- 总死亡率为4.1%;25.2%需要机械通风,特别是新生儿和幼儿,死亡率显著增加 (OR 16.6).
结论:
- 在儿童中,CSVT并不常见,并且呈现出U形的年龄分布.
- 脑卒中是儿科CSVT的常见并发症,显著增加死亡风险和机械通风的需要.
- 机械通风在CSVT的婴儿中更常见,并且与所有儿科年龄组的死亡率增加密切相关.
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