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Updated: Jul 23, 2025

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

Published on: September 16, 2022

在临床决策中使用ctDNA的实用建议

Stacey A Cohen^1,2, Minetta C Liu³, Alexey Aleshin³

¹Fred Hutchinson Cancer Center, Seattle, WA, USA. shiovitz@uw.edu.

|July 12, 2023

概括

循环瘤DNA (ctDNA) 显示出早期癌症复发检测和治疗监测的前景. 本综述为解释临床实践中的ctDNA分析提供了一般性建议,特别是对于固体瘤.

科学领域:

癌症学
生物标志物发现
临床诊断

背景情况:

癌症治疗的改善减少了死亡率.
早期发现复发对于有效管理至关重要.
基于血液的生物标志物如循环瘤DNA (ctDNA) 是新兴的工具.

研究的目的:

提供关于ctDNA临床功效的一般建议.
在各种治疗环境中指导ctDNA分析的解释.
澄清ctDNA在固体瘤患者中的含义,优点和局限性.

主要方法:

对ctDNA实用性的新兴现实数据的审查.
分析现有的观察性和适应性研究.
综合信息,制定一般临床建议.

主要成果:

ctDNA越来越多地用于检测分子残留疾病.
在治疗反应监测和优化监测中提供ctDNA辅助.
证据表明ctDNA是复发的敏感和特定生物标志物.

结论:

在治疗癌症,特别是固体瘤方面,ctDNA具有显著的潜力.

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了解ctDNA的优势和局限性是临床应用的关键.

在实践中解释ctDNA结果的一般建议.