从电子健康记录中估计药物坚持:比较挖掘和处理喘治疗处方的方法
Holly Tibble1,2, Aziz Sheikh3,4, Athanasios Tsanas3,4
1Usher Institute, University of Edinburgh, Edinburgh, Scotland. htibble@ed.ac.uk.
BMC medical research methodology
|July 12, 2023
概括
使用不同的方法从电子健康记录 (EHR) 中估计药物坚持,可以得到不同的结果. 了解这些差异对于准确的患者执法评估和改善疾病管理至关重要.
科学领域:
- 医疗信息学 医疗信息学
- 药物经济学 药物经济学
- 临床药房 临床药房
背景情况:
- 药物坚持,即处方和实际药物使用之间的协议,对于疾病控制至关重要.
- 电子健康记录 (EHR) 提供了一种方法,通过将处方药与处方药进行比较来估计遵守.
- 对于电子健康记录中的依从度测量,没有普遍的标准,需要对不同的方法进行批判性评估.
研究的目的:
- 在一个大型的,纵向的苏格兰EHR数据集中,批判性地评估各种药物坚持措施.
- 确定影响不同依从性估计方法之间的差异的关键因素.
- 为研究人员在为特定应用选择合适的合规措施时提供指导.
主要方法:
- 利用91,334名喘患者的队列,这种疾病的不坚持率很高.
- 计算了八种不同的药物坚持措施.
- 比较了从处方中估计药物供应持续时间的不同方法.
主要成果:
- 在不同措施的遵守估计中观察到显著的差异.
- 不一致的关键驱动因素包括预期的药物持续时间,处方重叠和治疗中止.
- 研究特定的因素也极大地影响了依从度的比较.
结论:
- 该研究强调了各种药物坚持措施的局限性.
- 强调在选择坚持措施时考虑数据,条件和人口特征的重要性.
- 旨在使研究人员能够做出明智的方法选择,以便有意义地捕获坚持.
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