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胰岛素生长因子轴和糖尿病病中的心风险:来自CREDENCE试验的分析
Reza Mohebi1, Yuxi Liu1, Michael K Hansen2
1Cardiology Division, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
胰岛素样生长因子-1 (IGF-1) 和IGF-1/IGFBP-3比率升高与2型糖尿病患者心脏脏风险增加有关. 卡纳格利弗洛辛治疗没有改变这些IGF标记物.
科学领域:
- 内分泌学和新陈代谢学
- 心血管研究研究心血管研究
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 胰岛素类生长因子 (IGF) 调节细胞增殖和新陈代谢.
- IGF-1与IGF结合蛋白-3 (IGFBP-3) 的比率影响了IGF-1的生物活性.
- 在2型糖尿病 (T2D) 中研究IGF-1和IGFBP-3具有心脏结局至关重要.
研究的目的:
- 检查IGF-1,IGFBP-3之间的关联,以及它们与T2D患者心脏结局的比率.
- 评估卡纳格利弗洛辛治疗对IGF-1和IGFBP-3水平的影响.
主要方法:
- 从CREDENCE试验中分析了2627名患有慢性病的T2D患者.
- 在基线,第一年和第三年测量IGF-1和IGFBP-3.
- 考克斯比例危险回归以评估与主要复合心结局的关联.
主要成果:
- 升高的IGF-1与减少的淋巴膜过率以及复合心事件和全因死亡率的风险增加相关.
- 增加IGF-1/IGFBP-3比率与初级复合结局的风险更高有关.
- 卡纳格利弗洛辛治疗在3年内没有显著改变IGF-1或IGFBP-3度.
结论:
- 在T2D中,IGF生物学在心脏脏风险中发挥着重要作用.
- 尽管对结果产生影响,但用卡纳格利弗洛辛抑制SGLT2似乎不会影响IGF生物学.
- 对IGF通路的进一步研究可能为T2D并发症提供新的治疗点.
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