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Updated: Jul 23, 2025

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下一代测序揭示了来自结直肠癌患者的血细胞外囊泡中的线粒基因组多样性

Tonje Bjørnetrø1, Paula A Bousquet2, Kathrine Røe Redalen3

  • 1Department of Oncology, Akershus University Hospital, P.O. Box 1000, 1478, Lørenskog, Norway. tonje.bjornetro@ahus.no.

BMC cancer
|July 12, 2023
PubMed
概括

从结直肠癌 (CRC) 患者的细胞外囊泡 (EV) 中的无细胞线粒体DNA (mtDNA) 显示出比全血mtDNA更大的多样性和更低水平的变异. 这种EV mtDNA具有更高比例的误解突变,影响线粒体蛋白质功能.

关键词:
结肠直肠癌是一种癌症.细胞外囊泡中的细胞外囊泡.这是下一代测序.我们的mtDNA mtDNA

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