美国患者对长期艾滋病治疗的偏好:一个离散选择实验
Susan M Graham1,2,3, Douglas Barthold4, Brett Hauber4,5
1Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.
Journal of the International AIDS Society
|July 13, 2023
概括
长效抗逆转录病毒疗法 (LA-ART) 提供了新的HIV治疗选择. LA口服药片比目前的每日治疗更受欢迎,而注射和植入物可能对一些艾滋病毒感染者来说是可以接受的.
科学领域:
- 艾滋病毒/艾滋病研究研究
- 药理学 药理学是指药理学的学科.
- 以患者为中心的护理
背景情况:
- 长效抗逆转录病毒疗法 (LA-ART) 为改善艾滋病毒感染者 (PWH) 治疗坚持和治疗结果提供了一个有希望的途径.
- 患者的偏好对于成功实施和采用新型LA-ART疗法至关重要.
研究的目的:
- 评估美国艾滋病毒感染者 (PWH) 对潜在的长效抗逆转录病毒疗法 (LA-ART) 方案的关键特征的偏好.
- 为了比较患者的偏好在不同的LA-ART给药方式,包括口服药片,皮下注射,肌内注射和植入物.
主要方法:
- 在美国的两个地点进行了一项离散选择实验,使用700个PWH.
- 参与者根据治疗方式,剂量频率,注射位置和与注射相关的疼痛等属性评估了假设的LA-ART疗法.
- 使用条件后勤回归来分析不同属性级别的偏好权重.
主要成果:
- LA口服片是目前每日口服治疗中首选的唯一LA-ART模式.
- 每年植入物和注射是下一个最喜欢的LA-ART选择.
- 首选在家用,而不是在诊所或药房用,并且更长的剂量间隔更受青.
结论:
- 许多PWH可能会很好地接受LA口服片,这可能会在日常口服疗法上带来优势.
- 延长持续时间的LA-ART注射和植入物可能被一小部分患者接受.
- 需要进一步的研究来了解偏好异质性,并预测新兴LA-ART产品的吸收和坚持.
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