双响应的pH/GSH超分子纳米药物用于低氧激活组合疗法
Chang Du1, Chenwei Wang2, Shu-Heng Jiang1
1State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Biomaterials science
|July 13, 2023
概括
这项研究引入了一种新的纳米药物,PFC/GOD-TPZ,可以克服瘤中低氧水平. 它有效地结合了饥饿疗法,化学动力学疗法和低氧激活化疗,以加强癌症治疗.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 瘤中的缺氧限制了缺氧激活前期药物的有效性.
- 开发先进的纳米载体对于提高癌症治疗疗效至关重要.
研究的目的:
- 为增强瘤治疗设计含铁素的超分子纳米药物 (PFC/GOD-TPZ).
- 在纳米医药中共同封装提拉巴胺 (TPZ) 和葡萄糖氧化酶 (GOD).
- 为了研究组合治疗的协同效应.
主要方法:
- 设计PFC/GOD-TPZ,具有pH敏感的PEG冠状和二硫化物键交叉连接的核心.
- 利用了涉及葡萄糖氧化酶,葡萄糖,氧气和铁的级联反应来生成H2O2.
- 在低毒瘤微环境中触发TPZ激活到细胞毒性津 (BTZ) 基.
主要成果:
- 实现了对PEG冠状体的pH响应分离,以增强细胞吸收.
- 证明了谷氨 (GSH) 触发的药物从核心释放.
- 在瘤缺氧下通过级联反应和芬顿化学成功激活TPZ.
结论:
- PFC/GOD-TPZ为组合治疗提供了一个有前途的策略.
- 这种纳米药物集成了葡萄糖氧化酶介导的饥饿疗法,化学动力学疗法 (CDT) 和低氧激活化疗法 (CT).
- 这种方法有效地解决瘤缺氧,以提高治疗结果.
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