供体生物变异对冷藏血小板质量和功能的影响
Alice Lorusso1, Harry Croxon1, Sarah Faherty-O'Donnell1
1Irish Blood Transfusion Service, National Blood Centre, Dublin, Ireland.
Vox sanguinis
|July 13, 2023
概括
捐赠者的BMI显著影响冷储血小板 (CSP) 的质量和功能. 室温储存血小板 (RTPs) 也表现出变化. 需要新的质量标记来进行CSP评估.
科学领域:
- 输血医学 输血医学
- 血液学 血液学 血液学
- 血液组分疗法是一种血液组分疗法.
背景情况:
- 室温储存血小板 (RTPs) 提供了更好的生存能力,但保质期更短.
- 冷藏血小板 (CSP) 的保质期较长,但可能会出现质量退化.
- 献血者的变异性是血液成分质量的重要因素.
研究的目的:
- 调查捐赠者变异性对CSP和RTP的影响.
- 评估RTP的质量标记是否适合CSP.
- 为了确定影响血小板质量的特定供体特征.
主要方法:
- 从男性捐赠者那里收集了10个双重血小板捐赠,并分为CSP和RTP组.
- 血小板质量和功能在储存7天后和第8天被评估.
- 记录了包括身体质量指数 (BMI) 在内的捐赠者人口统计数据.
主要成果:
- 在CSP和RTP之间观察到血小板度和旋转的显著差异.
- 在储存期间,CSP显示激活和亡标志物的增加.
- 较高的供体BMI (>29) 与较低的血小板度和CSP中的激活相关.
结论:
- 捐赠者的BMI显然影响了CSP的质量和功能.
- 目前的质量标记可能不足以评估CSP.
- 对CSP的新型质量标志物进行进一步研究是有必要的.
相关概念视频
Bone Marrow Sampling and Transplants
360
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
360
Structure and Function of Platelets
1.3K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
1.3K
Blood Transfusion
616
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
616
Blood Transfusion and Agglutination
10.9K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
10.9K


