青少年的体力活动可以防止以后生活中因异二醇引起的心脏功能障碍
Aykhan Yusifov1, Megan O Borders1, MacKenzie A DeHoff1
1Division of Kinesiology and Health, University of Wyoming, Laramie, Wyoming, United States.
Journal of applied physiology (Bethesda, Md. : 1985)
|July 13, 2023
概括
早期的生活运动,特别是青少年小鼠的自愿轮子运行,提供了对晚年心脏压力的持久心脏保护. 这种早期活动有助于预防诸如缩和纤维化等有害变化,这表明长期的心血管益处.
科学领域:
- 心血管生理学心血管生理学
- 运动科学 运动科学
- 发展生物学 发展生物学
背景情况:
- 心血管疾病对公众健康构成重大挑战,特别是在老年人群中.
- 运动是心脏健康的关键干预措施,在发育期可能产生更大的影响.
- 青少年心脏的可塑性可能为长期心脏保护性适应提供了一个独特的窗口.
研究的目的:
- 为了研究青少年小鼠的自愿运动是否会在以后的生活中提供心脏保护.
- 为了确定早期的身体活动是否可以减轻心脏功能障碍和成年期因压力而引起的重塑.
- 探索潜在的分子机制,如上腺素受体表达,是这种保护的基础.
主要方法:
- 年轻小鼠 (3周大) 参与了2周的自愿轮子运行.
- 然后,在使用异二醇 (ISO) 诱导心脏应激之前,小鼠被老化到成年 (4-6个月).
- 评估了心脏功能,肌细胞大小,纤维化和上腺素受体表达,并在各组 (早期跑步者,成人跑步者,久坐式对照) 中进行了比较.
主要成果:
- 早期的运动显著减轻了ISO诱导的心脏质量,肌细胞大小和纤维化.
- 由ISO引起的心脏功能缺陷 (射出分数,分数缩短) 在男性青少年跑步者中被逆转.
- 在青少年男性跑步者中观察到上腺素受体表达的下调,并持续到成年,与保护相关.
结论:
- 生命早期的自愿体力活动会诱导持续的心脏适应,从而保护成人免受压力诱导的心脏重塑和功能障碍.
- 在早期运动后,上腺素受体的降低调节可能是一个关键的机制,在以后的生活中赋予了对心脏压力的弹性.
- 这些发现突出了早期活动的潜力,以建立持久的心血管健康益处,强调运动作为整个生命周期的药物.
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