肺叶片滑动在呼吸过程中对细胞扭曲的作用
Adam E Galloy1, Joseph M Reinhardt1, Madhavan L Raghavan1
1Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa, United States.
Journal of applied physiology (Bethesda, Md. : 1985)
|July 13, 2023
概括
肺部叶片滑动可以减少呼吸过程中的对酶体扭曲. 计算模型显示,允许叶片滑动显著降低了肺扭曲,而不是禁止它,特别是在下叶.
科学领域:
- 肺部生物力学 肺部生物力学
- 计算生物学 计算生物学
- 医疗成像医学成像
背景情况:
- 肺部裂沿着叶片滑动是肺部力学中鲜为人知的机制.
- 了解叶片滑动可能会解释由于解剖学差异的呼吸变化,如不完整的裂.
研究的目的:
- 为了测试叶片滑动在呼吸过程中减少肺膜扭曲的假设.
- 使用计算模型量化叶片滑动对肺力学的影响.
主要方法:
- 使用医学成像数据开发了人类左肺的有限元素模型.
- 与非线性有限弹性接触力学模拟进行了比较,其中有或没有叶片滑动.
- 使用异性变形指数 (ADI) 量化肺部扭曲.
主要成果:
- 允许叶片滑动的模型比不允许它的模型显示平均ADI (较少的对酶体扭曲) 显着较低.
- 这种效应在潮呼吸期间 (5.3%的中位数差异) 和喘息之间 (3.2%的中位数差异) 具有统计学意义.
- 叶片滑动的减少扭曲的效果在下叶最明显,与滑动的程度相关.
结论:
- 研究结果支持这样一个假设:肺叶部滑动可以减少呼吸过程中对酶体的扭曲.
- 腰部滑动似乎是保持呼吸期间肺组织完整性的重要因素.
- 计算模型为复杂的肺机械提供了宝贵的见解.
相关概念视频
Gross Anatomy of the Lungs
2.2K
The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
2.2K
Anatomy of Respiratory System II: Lower Respiratory Tract
1.2K
The lower respiratory tract is anatomically composed of several vital structures, including the larynx, trachea, bronchial tree, alveoli, lungs, and pleurae. Each component has a specific function, and all are intricately connected to ensure efficient respiration.
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...
1.2K
Breathing
59.7K
The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
59.7K
Pulmonary Cycle: Exhalation
1.6K
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
1.6K
Pleura of the Lungs
2.3K
The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
2.3K
Pressure Relationships in Thoracic Cavity
2.6K
Breathing, otherwise known as pulmonary ventilation, is the process of air movement into and out of the lungs. The main mechanisms propelling pulmonary ventilation are atmospheric pressure (Patm), intra-pulmonary (Ppul ) or intra-alveolar pressure (Palv) within the alveoli, and intrapleural pressure (Pip) within the pleural cavity.
Breathing Mechanisms
Both intra-alveolar and intrapleural pressures rely on specific lung properties. The ability to breathe—allowing air to enter the lungs...
Breathing Mechanisms
Both intra-alveolar and intrapleural pressures rely on specific lung properties. The ability to breathe—allowing air to enter the lungs...
2.6K


