急性热暴露对压力器对自愿低氧性呼吸暂停反应的影响
Holden W Hemingway1, Rauchelle E Richey1, Amy M Moore1
1Human Vascular Physiology Laboratory, Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, United States.
Journal of applied physiology (Bethesda, Md. : 1985)
|July 13, 2023
概括
预先暴露于热量会降低自愿低氧性呼吸暂停期间血压升高的情况. 这表明一个交叉压力效应,热度适应改变了身体对低氧和喘息的反应.
科学领域:
- 心血管生理学心血管生理学
- 自主神经系统调节自主神经系统调节
- 环境压力生理学生理学
背景情况:
- 对自愿性缺氧呼吸暂停的压力反应依赖于交感神经系统活动的增加.
- 急性热暴露会改变神经对血压的控制,但其对缺氧呼吸暂停反应的影响尚不清楚.
研究的目的:
- 调查先前的热暴露是否会在自愿性低氧性呼吸暂停期间减弱压力器反应.
主要方法:
- 11名健康成年人接受了被动全身加热,以提高核心温度1.2°C.
- 自发性缺氧呼吸暂停在正常热量 (基线) 和加热后恢复期间进行.
- 在15秒的呼吸暂停之前,参与者呼吸的氧气度各不相同 (21%,16%,12%).
主要成果:
- 在呼吸暂停期间动脉氧和度的变化在基线和恢复之间没有区别.
- 自发性缺氧性呼吸暂停的压力反应在加热后的恢复阶段显著降低.
- 在所有测试的氧气度 (21%,16%,12%) 中都观察到降低.
结论:
- 急性热暴露会产生交叉压力效应,减弱压力器对自愿缺氧呼吸暂停的反应.
- 这表明热度适应改变了交感外流和心血管对缺氧压力的调整.
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