来自年轻大鼠的便微生物群移植减轻了通过多组学分析揭示的与年龄相关的肉症
Xiaoxing Mo1, Lihui Shen1, Ruijie Cheng1
1Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Journal of cachexia, sarcopenia and muscle
|July 13, 2023
概括
来自年轻捐赠者的便微生物群移植 (yFMT) 通过恢复肠道微生物群和屏障完整性,改善了老老鼠的肌肉质量,力量和功能. 这表明yFMT可能是与年龄相关的肉症的新疗法策略.
科学领域:
- 老年学是一门学科.
- 微生物学 微生物学
- 肌肉生理学 肌肉生理学
背景情况:
- 肌肉质量和力量的与年龄相关的损失萨科佩尼亚受肠道微生物群通过"肠-肌肉"轴的影响.
- 益生菌为肉症提供了潜在的治疗途径,由于其益生菌效应,从年轻捐赠者 (yFMT) 获得便微生物群移植 (FMT) 显示出有前途.
研究的目的:
- 调查yFMT在老老鼠中缓解与年龄相关的肉症的疗效.
- 阐明yFMT影响骨肌肉健康和肠道功能的潜在机制.
主要方法:
- 老老鼠接受了8周的便微生物群移植,来自年轻或老的捐赠者.
- 评估肌肉质量,力量,功能,缩和再生能力.
- 分析了便微生物群组成 (16S rRNA),血清代谢量,肠道屏障完整性和肌肉转录组.
主要成果:
- 在老老老鼠中,yFMT显著改善了肌肉质量,强度和功能,抵消了与年龄相关的肌肉缩并增强了再生.
- yFMT改善了肠道失调,增加了有益的细菌和代谢物,并恢复了肠道屏障的完整性.
- yFMT改善了线粒体生物发生和肌肉功能,在肠道微生物群变化和肉症表型之间发现了相关性.
结论:
- yFMT有效地重塑了肠道微生物群和代谢物,保持了肠道屏障的完整性,并改善了肌肉线粒体功能,从而减轻了老老鼠的肉症.
- yFMT提出了一种有前途的新治疗策略,用于对抗与年龄相关的肉症.
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