在体内和体外,发育中的脏的内化
Julia Tarnick1, Mona Elhendawi1, Ian Holland1
1Deanery of Biomedical Science, University of Edinburgh, Edinburgh EH8 9XD, UK.
Biology open
|July 13, 2023
概括
脏发育涉及神经和血管. 在正在发育的小鼠脏中,神经纤维 (神经细胞) 在光滑肌肉细胞被招募形成动脉后到达,这表明它们不指导这个过程.
科学领域:
- 发展生物学 发展生物学
- 神经科学是一个神经科学.
- 脏生理学 脏生理学
背景情况:
- 成年人脏中存在神经炎,调节血液流动.
- 发育过程中内置的作用和时间尚不清楚.
- 在其他发育中的组织中已知神经元在动脉分化中的作用.
研究的目的:
- 研究神经在小鼠脏动脉发育中的潜在作用.
- 为了确定神经元内置时间是否与动脉光滑肌肉细胞招募相关.
主要方法:
- 采用了整体的免疫光染色.
- 该研究的重点是小鼠脏发育.
主要成果:
- 小鼠脏的神经内置发生在胚胎日13.5和14.5.5之间.
- 在显著的神经元内置之前,光滑肌肉中活性蛋白阳性细胞被招募到动脉中.
结论:
- 神经炎似乎没有指导最初的光滑肌细胞招募到动脉的发展.
- 时间表明,在血管发育的后期阶段,神经起着不同的作用.
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