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相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

822
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

1.0K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

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The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
892
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

1.8K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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相关实验视频

Updated: Jul 23, 2025

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
10:31

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

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在亚托皮性皮肤炎中的CLA+记忆T细胞.

Lídia Sans-de San Nicolàs1, Tali Czarnowicki2, Mübeccel Akdis3

  • 1Immunologia Translacional, Departament de Biologia Cel·lular, Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona (UB), Parc Científic de Barcelona (PCB), Barcelona, Spain.

Allergy
|July 13, 2023
PubMed
概括

皮肤淋巴细胞关联抗原 (CLA) + T 细胞是皮炎的关键参与者,影响免疫反应,像这样的症状和治疗疗效. 了解这些细胞可以了解皮肤疾病.

关键词:
在CLA+ T细胞中.亚托邦性皮肤炎的发生.生物标志物生物标志物皮肤 - 养家庭翻译工作的翻译工作.

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Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions
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Generation and Culturing of Primary Human Keratinocytes from Adult Skin
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相关实验视频

Last Updated: Jul 23, 2025

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
10:31

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

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Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions
05:58

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Generation and Culturing of Primary Human Keratinocytes from Adult Skin

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科学领域:

  • 免疫学 免疫学 免疫学
  • 皮肤病学 皮肤病学
  • 细胞生物学 细胞生物学

背景情况:

  • 亚托邦性皮肤炎涉及复杂的免疫失调.
  • 皮肤淋巴细胞相关抗原 (CLA) + T 细胞是回归到皮肤的记忆 T 细胞的一个子集.
  • 这些细胞在皮肤炎症和免疫反应中起作用.

研究的目的:

  • 审查关于在亚托皮性皮肤炎病理学中的CLA + T细胞机制的翻译信息.
  • 巩固对CLA+ T细胞与疾病机制,生物标志物和治疗相关的理解.

主要方法:

  • 在亚托皮性皮肤炎中对CLA + T细胞的研究的文献综述.
  • 分析了CLA+ T细胞与疾病特异性因素 (如金黄色葡萄球菌,Th2反应,IL-13,IL-31和) 之间的关联.
  • 检查CLA+ T细胞参与向治疗机制的研究,包括dupilumab.

主要成果:

  • CLA+ T 细胞与金黄色葡萄球菌机制以及在亚托皮炎中异常的 Th2 免疫反应有关.
  • 诸如IL-13,IL-31和等因素与CLA+ T细胞活性有关.
  • 在患者中,dupilumab治疗的早期影响与CLA+ T细胞机制有关.

结论:

  • CLA+ T细胞对于理解亚托皮性皮肤炎的发病过程至关重要.
  • 它们的功能与皮肤相关的淋巴组织中的T细胞保持一致,这解释了它们在各种皮肤疾病中的作用.
  • 准CLA+T细胞可能是治疗亚托皮炎和其他T细胞介导的皮肤疾病的治疗策略.