选择性育种用于小鼠的高自愿性运动增加了最大 (V ̇O2,max),但不是基底代谢率
Nicole E Schwartz1, Monica P McNamara1, Jocelyn M Orozco1
1Department of Evolution, Ecology, and Organismal Biology, University of California, Riverside, Riverside, CA 92521, USA.
The Journal of experimental biology
|July 13, 2023
概括
选择性育种用于高自愿性运动的小鼠增加了最大有氧容量 (V·O2,max),但不是基底代谢率 (BMR) 或器官大小. 这表明行为特征可以在没有相应的生理修改的情况下发生变化.
科学领域:
- 运动生理学 运动生理学
- 代谢研究的研究.
- 动物繁殖 动物繁殖
背景情况:
- 持续的体力活动通常需要高的最大有氧容量 (V·O2,max).
- 由于共享的生理路径,最大的有氧能力可能需要高的基础代谢率 (BMR).
- 人工选择是一种强大的工具,用于研究复杂特征的遗传基础.
研究的目的:
- 为了研究是否选择性育种在小鼠中高自愿性运动提高V·O2,max和BMR.
- 确定这些生理变化是否与内部器官大小增加有关.
- 探索VO2,max,BMR和器官质量之间的关系.
主要方法:
- 利用来自人工选择实验的72只雌性小鼠 (高跑者线与控制线).
- 测量V·O2,max和BMR,根据体重进行调整.
- 评估身体组成和内部器官的质量 (心室,肌肉,肝脏,脏,脏,肺,大脑).
主要成果:
- 与对照组相比,高跑者小鼠的V̇O2,max显著增加 (+13.6%).
- 在高跑者和对照线之间没有观察到BMR的显著差异.
- 没有发现身体组成或器官质量 (调整为体重) 的显著差异.
- V̇O2,max和BMR没有相关性,只有心室质量与V̇O2,max有显著的相关性.
结论:
- 选择性育种用于高自愿性运动增加了最大有氧能力,但并没有增加小鼠的基础代谢率.
- 高度运动行为不一定会导致器官大小或基本代谢的比例增加.
- 行为特征可以通过选择独立于潜在的生理和形态适应而被修改.
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