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Updated: Jul 23, 2025

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
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Published on: March 31, 2019

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包括所有11个指在内的CTCF-DNA复合物的结构

Jie Yang1, John R Horton1, Bin Liu1

  • 1Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Nucleic acids research
|July 13, 2023
PubMed
概括

CCCTC-结合因子 (CTCF) 使用其指 (ZF) 域来结合DNA. 结构分析揭示了ZF1-ZF7和ZF8-ZF11在识别DNA序列中的不同角色,解释了高亲和度结合.

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