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Updated: Jul 23, 2025

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电子输送链和mTOR抑制协同降低CD40信号传递,并抵消慢性淋巴细胞白血病中的venetoclax抵抗

Zhenghao Chen1, Gaspard Cretenet1, Valeria Carnazzo2

  • 1Experimental Immunology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands; Hematology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands; Amsterdam Institute for Infection and Immunity, Cancer Immunology, Amsterdam, The Netherlands; Cancer Center Amsterdam, Cancer Immunology, Amsterdam, The Netherlands; Lymphoma and Myeloma Center, Amsterdam.

Haematologica
|July 13, 2023
PubMed
概括

CD40刺激促进慢性淋巴细胞白血病 (CLL) 细胞的代谢变化,导致对venetoclax的抵抗. 抑制电子传输链和mTOR通路可以克服这种阻力,提供潜在的治疗策略.

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