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血清微RNA-501-3p是检测轻度认知障碍的潜在诊断工具:Ehime基因组研究

Kensuke Toyama^1,2,3,4, Joshua M Spin^3,4, Philip S Tsao^3,4

¹Department of Pharmacology, Ehime University Graduate School of Medicine, Ehime, Japan.

Journal of neurochemistry

|July 13, 2023

概括

血液外体中的miR-501-3p升高可能表明轻度认知障碍 (MCI). 这一发现可以通过风险因素管理,更早地检测血管损伤,并可能通过风险因素管理减缓痴呆症的进展.

科学领域:

神经科学是一个神经科学.
生物标志物生物标志物
血管生物学血管生物学

背景情况:

血脑屏障 (BBB) 的破坏与认知能力下降有关.
miR-501-3p负面调节紧张的结点,导致BBB分解和血管认知障碍.
白质病变和BBB分解在血管轻度认知障碍 (MCI) 中很常见.

研究的目的:

调查血清外体 miR-501-3p 水平是否可以作为检测轻度认知障碍 (MCI) 的临床指标.
为了测试早期MCI患者表现出升高的miR-501-3p表达的假设.

主要方法:

招募了178名受试者 (平均年龄为73岁).
使用日本版本的蒙特利尔认知评估 (MoCA-J) 评估MCI.
使用定量聚合酶链反应 (qPCR) 测量了血清外体 miR-501-3p 水平.
根据ROC曲线分析将受试者分为"高"和"低"的miR-501-3p表达群.

主要成果:

在高MIR-501-3p组 (63.5%) 与低MIR-501-3p组 (47.1%) 相比,MCI的检测频率更高.
高的miR-501-3p表达与MCI状态显著相关 (几率比为2.662).
在非糖尿病患者和动脉样硬化患者中,这种关联仍然显著.

结论:

血外体miR-501-3p水平升高可能表明患者患有MCI.
通过miR-501-3p早期检测血管损伤可能使干预措施能够减少痴呆症的进展.
管理血管风险因素对于减轻渐进性痴呆症至关重要.

关键词:

在外基因组中,外基因组是外基因组.在 miR-501-3p 中.轻度的认知障碍轻度的认知障碍

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相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...