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基于核磁共振的新型海洋甘氨酸和衍生的寡糖化合物的结构阐明

Rohini Dwivedi¹, Antim K Maurya¹, Hoda Ahmed¹

¹Department of BioMolecular Sciences, University of Mississippi, University, Mississippi, USA.

Magnetic resonance in chemistry : MRC

|July 13, 2023

概括

海洋甘氨酸提供独特的生物作用,并使结构-活性关系研究成为可能. 核磁共振 (NMR) 光谱对于阐明这些复杂的海洋糖的结构至关重要,包括硫酸多糖和寡糖.

科学领域:

海洋天然产品化学海洋天然产品化学
碳水化合物的化学成分
结构生物学是结构生物学.

背景情况:

海洋甘氨酸具有独特的生物活动和明确的结构,非常适合进行结构-活性关系 (SAR) 研究.
海洋多糖的高分子量可能会阻碍生物物理和分析研究.
制备低分子量寡糖是一种促进研究的策略.

研究的目的:

重新探讨并介绍各种海洋硫酸多/寡糖的基于核磁共振 (NMR) 的结构阐明.
突出NMR光谱在确定复杂的海洋甘氨酸的结构中的实用性.

主要方法:

核磁共振 (NMR) 光谱学,包括1D和2D同核和异核实验.
分析特定的1H和13C化学转移以进行结构确定.
提取和制备海洋多糖和寡糖.

主要成果:

来自*Marcia hiantina*的α-葡萄糖的结构阐明.
来自红藻Botryocladia occidentalis*的两个硫酸银河体的表征.
从 *Pentacta pygmaea* 和其衍生的寡糖化合物中确定基化ondroitin硫酸盐的结构.
分析来自*Holothuria floridana*的基化氏素硫酸盐的寡糖类.
来自Holothuria floridana*的硫酸的结构阐释.

结论:

核磁共振光谱是一种关键技术,用于阐明各种海洋硫酸多/寡糖的结构.
在SAR研究中,海洋甘氨酸的定义结构是必不可少的.
本研究详细介绍了几种新型海洋甘氨酸的NMR衍生结构.

关键词:

13C 13C 13C 13C 13C 13C 13C 13C 13C 13C 13C 13C 13C 13C 13C 13C 13C 13C 一个小时 1H 1H 这是NMR的NMR.福克苏化氏丁硫酸盐福克苏化氏丁硫酸盐糖酸链接糖酸链接糖酸链接有机糖类 (Oligosaccharides) 是一种糖类.硫酸富干硫酸盐的使用情况硫酸硫酸银河体的银河体硫化模式的硫化模式 α-葡萄糖是一种

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