P2X7-受体通路参与药用植物的抗炎活性
Sergio Ortiz1,2, Katarina Šavikin3, France Massicot4
1Team Natural Products, Analyzes and Syntheses, Université Paris Cité, CNRS, Faculté de Pharmacie de, 4 Avenue de l'Observatoire F, 75006, Paris, France.
Chemistry & biodiversity
|July 13, 2023
概括
欧洲民间药用植物,特别是Scrophularia和Plantago,显著抑制纯能受体P2X7的激活,这表明涉及harpagoside的新型抗炎机制.
科学领域:
- 药理学和民族植物学
- 炎症研究的研究.
- purinergic 信号传递 纯能信号传递
背景情况:
- 欧洲民间医学利用来自Lamiiales,Gentianales和Asterales的植物来治疗炎症疾病.
- 纯能受体P2X7激活在炎症中的作用在很大程度上仍未被探索.
- 识别新的抗炎标和天然化合物对于治疗进步至关重要.
研究的目的:
- 为了研究欧洲民间药用植物提取物对纯能受体P2X7激活的抑制作用.
- 探索这些植物作为针对P2X7.7的新型抗炎药物的来源的潜力.
- 为了确定负责P2X7抑制的特定化合物.
主要方法:
- 在体外生物测试使用YO-PRO-1吸收染料测量P2X7激活.
- 从欧洲民间医学中选植物提取物.
- 超高性能液体染色学与质谱学 (UPLC/MS),脱复制和代谢分析相结合,用于化合物识别.
主要成果:
- 一些植物提取物显著抑制了P2X7激活 (>50%在0.1和1μg/mL).
- 来自Scrophularia和Plantago属的物种特别有效.
- 一种 cinnamoyl-iridoid 的 harpagoside 被确定为 Scrophularia 提取物中 P2X7 激活的潜在抑制剂.
结论:
- 来自Scrophularia和Plantago属的药用植物具有可以抑制P2X7激活的化合物.
- 丁胺-化物,如harpagoside,可能代表一种具有抗炎功能的新类P2X7抑制剂.
- 这项研究为研究涉及P2X7受体和肉-化含植物的抗炎机制开辟了新的途径.
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