在选定的艾滋病毒诊所中为艾滋病毒/艾滋病毒共感染者创建一个纵向的HCV护理布,使用数据来护理方法
Ralph Brooks1, Maximilian Wegener1, Suzanne Speers2
1Yale University, New Haven, CT, USA.
Health promotion practice
|July 13, 2023
概括
数据对护理方法改善了HIV/HCV共感染患者的C型肝炎病毒 (HCV) 治疗. 这种公共卫生方法提高了持续病毒学反应 (SVR) 率,总体达到71%,并确定了阻碍治疗开始的因素.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 临床医学 临床医学
背景情况:
- 直接作用抗病毒 (DAA) 疗法在消除C型肝炎病毒 (HCV) 方面具有很高的疗效.
- 焦点人群,包括那些艾滋病毒/HCV共感染的人群,需要定制的策略来获得治疗.
- 数据到护理 (D2C) 是一个公共卫生框架,旨在改善艾滋病毒感染者 (PWH) 的治疗级联.
研究的目的:
- 调整和实施D2C方法,以加强艾滋病毒/HCV共感染者之间的HCV治疗.
- 描述和改善康涅狄格州11家艾滋病毒诊所的HCV治疗级联.
- 确定与治疗启动和持续病毒学反应 (SVR) 相关的因素.
主要方法:
- 利用D2C方法,将诊所生成的患者名单与全州HCV监测系统相匹配.
- 与当地临床冠军和数据工作人员合作,以提高质量和实践转型.
- 开发了临床水平的HCV治疗级联,使用DPH数据,包括居住率和死亡率,进行纵向分析.
主要成果:
- 分析了1496名HIV/HCV共感染患者的队列.
- 到2020年9月,总体持续病毒学响应 (SVR) 率达到71%,临床水平有显著的变化 (44%-100%).
- 缺乏HCV治疗的开始与女性性别 (OR=2.18) 和缺乏HIV病毒抑制 (OR=3.24) 相关.
结论:
- D2C方法有效地表征和改进HIV/HCV共感染的个体的HCV治疗级联.
- 质量改善举措,包括数据精细化和治疗参与度增加,导致SVR率提高.
- 解决女性性别和HIV病毒抑制等障碍对于优化同感染人群中HCV治愈至关重要.
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