使用全麦的短期饮食干预可以防止抗生素诱导的失生症
Stephen K Costa1, Katherine Antosca1, Chapman N Beekman1
1Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA.
食麦可以防止抗生素诱导的肠道微生物组失调症 (AID). 在抗生素挑战期间补充麦的时间对于最大程度的保护至关重要,影响微生物群的结构和功能.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 胃肠病学 胃肠病学
背景情况:
- 抗生素诱导的肠道微生物组失调 (AID) 显著影响宿主健康.
- 已知饮食成分会影响AID,但确切的机制和时间尚不清楚.
研究的目的:
- 为了研究麦或乳糖补充饮食如何调节氨基素诱导的肠道微生物组结构和转录活性的变化.
- 为了确定饮食时间对抗艾滋病保护的影响.
主要方法:
- 使用多omics方法来分析肠道微生物组的变化.
- 给小鼠服用阿莫西西林,并加上各种麦或乳糖饮食干预措施 (在挑战期间,总是,或在恢复期间).
主要成果:
- 在阿莫西西林挑战期间的麦补充剂提供了与其他麦饮食时间相比,对艾滋病的最大保护.
- 麦饮食减轻了阿莫西西林驱动的 *Firmicutes* 的减少,并将肠道社区转向了抗生素压力管理.
- 摄取乳糖的社区表现出碳水化合物饥饿,有利于呼吸代谢和代谢压力.
结论:
- 饮食时间是缓解AID的关键因素,可能比单独的饮食成分更重要.
- 麦补充剂,特别是当在抗生素暴露期间服用时,代表了一种有前途的饮食干预策略,用于管理AID.
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