在SLE中使用葡萄糖皮质类药物治疗与感染,并发症和死亡率有关 - 一项国家队列研究
Martina Frodlund1, Andreas Jönsen2, Lauren Remkus3
1Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection/Rheumatology, Linköping University, Linköping, Sweden.
在全身性红斑狼 (SLE) 患者中,即使是低剂量的口服皮质类固醇 (OCS) 也会增加感染,并发病和死亡的风险. 以最低有效剂量合理使用OCS至关重要,以最大限度地减少SLE管理中的危害.
科学领域:
- 类风湿病学 类风湿病学
- 临床药理学 临床药理学
- 公共卫生 公共卫生
背景情况:
- 系统性红斑狼 (SLE) 患者面临更高的并发病风险和减少的存活率.
- 口服皮质类固醇 (OCS) 通常用于治疗SLE,但可能会导致不良结果.
研究的目的:
- 评估各种口服皮质类固醇 (OCS) 剂量值对SLE患者感染,并发症,恶性瘤和生存的预测值.
- 分析瑞典国家卫生登记处的数据,以评估OCS对SLE患者结果的影响.
主要方法:
- 利用了瑞典国家卫生登记处的数据,包括国家处方药登记处.
- 包括5309例发生的SLE病例 (年龄大于18岁) 和26545个匹配的人口控制从2005年到2020年.
- 使用时间依赖的考克斯回归模型来分析风险因素.
主要成果:
- 与没有OCS相比,所有OCS剂量值 (>0至<5.0毫克/天,5.0-7.5毫克/天,>7.5毫克/天) 都与感染,骨质疏松症,骨硬化,胃肠,白内障,高血压和死亡率的风险增加有关.
- 较低的OCS剂量 (0至<5.0毫克/天) 显示出相应疾病的危险比率低于较高剂量.
- 诊断后15年,48%的SLE患者使用OCS,平均剂量为5.7毫克/天.
结论:
- 研究结果表明,即使在SLE患者的低剂量OCS治疗中,也有潜在的危害.
- 强调需要在最低有效剂量中明智使用OCS,以平衡疗效并最大限度地减少SLE管理中的不良影响.
更多相关视频
10:21Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
07:25Author Spotlight: A Focus on Standardized Salivary Gland Ultrasound Protocol in Connective Tissue Disease Research
Published on: October 13, 2023
相关概念视频
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
COPD: Management Using Bronchodilators and Corticosteroids
Nephrotic Syndrome II : Assessment and Medical Management
