在孕妇中,异种COVID-19疫苗接种的免疫性和反应性
Chenchit Chayachinda1, Kanokwaroon Watananirun1, Chayawat Phatihattakorn1
1Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Human vaccines & immunotherapeutics
|July 13, 2023
概括
使用CoronaVac或ChAdOx1然后使用BNT162b2的异质COVID-19疫苗计划在孕妇中提供与同源BNT162b2相比的免疫性. 这些发现支持在mRNA有限的环境中采用替代疫苗接种策略.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 孕产妇健康 孕产妇健康
背景情况:
- 孕妇是COVID-19的脆弱人群之一.
- 评估疫苗在怀孕期间的有效性和安全性至关重要.
- 不同类型的疫苗接种策略可能在疫苗供应环境中提供灵活性.
研究的目的:
- 在怀孕的泰国妇女中比较异质和同质COVID-19疫苗计划的免疫性和反应性.
- 为了评估不同初级疫苗接种系列后的抗体反应和不良事件.
- 为了确定母体抗体转移到带血的情况.
主要方法:
- 一项开放的非劣势性试验将124名孕妇 (18-45岁) 随机分为三组.
- 组接受了两剂初级系列:BNT162b2-BNT162b2,ChAdOx1-BNT162b2,或CoronaVac-BNT162b2,4周间隔.
- 免疫性 (抗体水平) 和反应性 (不良事件) 被评估为疫苗接种后和分娩时.
主要成果:
- 在第二剂后2周,两组之间没有观察到抗受体结合域 (RBD) IgG的显著差异.
- 在CoronaVac-BNT162b2组中,中和抗体标位最高,其次是BNT162b2-BNT162b2和ChAdOx1-BNT162b2组.
- 带血抗体水平与母体水平相关,没有显著的群体差异. 副作用大多为轻度至中度,在ChAdOx1-BNT162b2组的频率更高.
结论:
- 异种COVID-19疫苗接种计划 (CoronaVac-BNT162b2或ChAdOx1-BNT162b2) 在孕妇中诱导与同源BNT162b2相似的免疫性.
- 这些异质序列可以被视为替代的初级序列选项,特别是在mRNA有限的环境中.
- 怀孕期间的疫苗接种有效地将抗体转移到新生儿身上.
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