怀孕 类似葡萄糖素的1预测胰岛素,但不是葡萄糖度
Danielle L Jones1, Clive J Petry1, Keith Burling2
1Metabolic Research Laboratories, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, CB2 0QQ, UK.
Acta diabetologica
|July 13, 2023
概括
胰岛素激素葡萄糖类1 (GLP-1) 水平预测孕妇的胰岛素水平,但不是葡萄糖水平. 其他因素对妊娠期糖尿病的发展更为关键.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 生殖生理学 生殖生理学
背景情况:
- 胰岛素激素,葡萄糖类1 (GLP-1) 和胃抑制 (GIP),增强非怀孕成年人的胰岛素分泌.
- 在怀孕期间,因胎盘而出现独特的荷尔蒙变化,不太了解素在怀孕期间的作用.
- 调查英克雷丁的功能对于了解妊娠期间的葡萄糖代谢至关重要.
研究的目的:
- 为了确定禁食和口服后葡萄糖耐受性测试 (OGTT) 的度是否预测孕妇的胰岛素和葡萄糖水平.
- 在怀孕期间评估GLP-1,GIP,胰岛素和葡萄糖之间的关系.
- 为了探索英克雷丁对妊娠期葡萄糖恒温的影响.
主要方法:
- 在怀孕28周招募了394名怀孕妇女,她们具有妊娠糖尿病风险因素.
- 进行了75g口服葡萄糖耐受性测试 (OGTT).
- 测量了禁食和120分钟后OGTT血中的葡萄糖,胰岛素,GLP-1和GIP的度.
主要成果:
- 禁食和OGTT后GLP-1度与胰岛素水平显著相关,独立于BMI.
- 在禁食或OGTT后的时间点,GLP-1度与葡萄糖水平没有相关性.
- 孕妇参与者的GIP度与胰岛素或葡萄糖水平没有关联.
结论:
- 在怀孕期间,因克雷丁和胰岛素之间的关联保持不变.
- GLP-1,但不是GIP,似乎可以预测孕妇的胰岛素度.
- 胎盘和逆调节激素可能在确定孕产妇血糖和妊娠糖尿病风险方面发挥更重要的作用,而不是单独使用隐形素.
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