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非编码RNA在人类癌症中的新兴作用

Shijie Wu¹, Yiwen Wu¹, Sijun Deng¹

¹School of Pharmaceutical Science, Hengyang Medical College, University of South China, 28 Western Changsheng Road, Hengyang, 421001, Hunan, People's Republic of China.

Discover oncology

|July 13, 2023

概括

非编码RNAs (ncRNAs),基因表达的关键调节者,涉及到各种人类癌症的发展和进展. 了解像microRNAs (miRNAs) 这样的ncRNA为新型癌症诊断和治疗提供了潜力.

科学领域:

分子生物学分子生物学
遗传学遗传学是一个
在瘤学瘤学.

背景情况:

大多数细胞RNA都是非编码RNA (ncRNA),在基因表达和人类病理学中起着重要作用.
包括miRNA,circRNA和lncRNA在内的ncRNA越来越多地被认为与癌症发展有关.
对ncRNAs的失调与胃癌,乳腺癌和肺癌等主要癌症的发生和预后有关.

研究的目的:

审查关键非编码RNAs (miRNA,circRNA,lncRNA) 的生物合成和特征.
阐明这些ncRNAs在人类癌症中的多方面的作用.
探索ncRNAs影响癌症进展的潜在机制.

主要方法:

关于ncRNA生物合成,特征和癌症中的功能的综合文献综述.
分析目前关于miRNA,circRNA和lncRNA在各种人类恶性瘤中的作用的研究.
检查将ncRNA失调与癌症发病症联系起来的分子机制.

主要成果:

确定了各种ncRNA在许多癌症类型中的基本作用.
突出显示微RNAs (miRNAs) 作为癌症研究的一个特别活跃的领域.
证实了ncRNA失衡与胃癌,乳腺癌和肺癌的发病率和预后之间的联系.

结论:

ncRNAs是人类癌症的关键参与者,影响疾病发展和患者的结果.
对ncRNA的进一步研究可能会产生用于癌症诊断和治疗点的新生物标志物.
了解ncRNA机制为开发创新的癌症治疗策略提供了基础.

关键词:

癌症癌症癌症癌症环RNA 环RNA 是一个环RNA.在ncRNA中,我们可以这是一个小RNARNA.这是一个ncRNARNA.

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